Perilous influence of diabetes mellitus on fertility: possible and progressive future approaches and treatments to cure

Authors

  • Moitra S Department of Zoology, University of Kalyani, Kalyani, Nadia, West Bengal, Pin-741235

DOI:

https://doi.org/10.70035/ijarts.2022.1141-44

Keywords:

Type 1 Diabetes, Type 2 Diabetes, Hyperglycemia, Infertility, Treatment

Abstract

Nowadays a huge number of people suffer from infertility throughout the world due to diabetes and irregular life-style. The number reaches 60-80 million globally. Diabetes mellitus is a chronic non-curable but manageable disease. According to the International Diabetes Federation (IDF) report released in November 2021, the number of adult people suffering from diabetes mellitus (DM) has risen from 108 million in 1980 to 537 million in 2021 and according to the previous IDF report, it was about 387 million in 2014 and 463 million in 2019. Type1 diabetes causes decrease in insulin level and degrades essential proteins of the body. Type 2 Diabetes Mellitus is the most common form of the diabetes mellitus and it was formerly known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes. This T2DM comprises a cluster of dysfunctions that is generally characterized by hyperglycemia and it results from the combined effect of relative insulin insufficiency or insufficient secretion of insulin, insulin resistance and excessive or uncontrolled glucagon secretion. The study focuses on diabetes associated infertility and treatments. Throughout various physiological mechanisms type1 and type2 diabetes mellitus affect male and female infertility. This finding thus creates a relationship between diabetes mellitus and infertili ty and possible effective treatments.

References

References

Alberti KGMM. and Zimmet PZ. 1998 WHO Consultation. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus. Provisional Report

of a WHO Consultation. Diabet. Med. 15 (7): 539–553. https://doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.

International Diabetes Federation. 2021 Diabetes now affects one in 10 adults worldwide. https://www.idf.org/news/240:diabetes-now-affects-one-in-10-adults-worldwide.html.

Sun H., Saeedi P., Karuranga S., Pinkepank M., Ogurtsova K., Duncan BB., Stein C., Basit A., Chan JC., Mbanya JC., Pavkov ME., Ramachandaran A., Wild SH., James S., Herman WH., Zhang P., Bommer C., Kuo S., Boyko

EJ. and Magliano DJ. 2021 IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabet. Res. Clinic. Pract. 109119, 183 (2022): 1-13.

https://doi.org/10.1016/j.diabres.2021.109119.

Saeedi P., Petersohn I., Salpea P., Malanda B., Karuranga S., Unwin N., Colagiuri S., Guariguata L., Motala AA., Ogurtsova K., Shaw JE., Bright D. and Williams R. 2019 Global and regional diabetes prevalence estimates for 2019

and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabet. Res. Clinic. Pract. 107843, 157 (2019): 1-10. https://doi.org/10.1016/j.diabres.2019.107843.

Wild S., Roglic G., Green A., Sicree R. and King H. 2004 Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabet. Care. 27(5): 1047–1053. https://doi.org/10.2337/diacare.27.5.1047.

Chen L., Magliano DJ. and Zimmet PZ. 2011 The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nat. Rev. Endocrinol. 8(4): 228–236. https://doi.org/10.1038/nrendo.2011.183.

Samadder A. and Khuda-Buksh AR. 2014 Nanotechnological approaches in diabetes treatment: A new horizon. World J Translation. Medi. 3(2): 84. https://doi.org/10.5528/wjtm.v3.i2.84.

Inhorn MC. and Patrizio P. 2015 Infertility around the Globe: New Thinking on Gender, Reproductive Technologies and Global Movements in the 21st Century. Hum. Reprod. Update. 21 (4): 411–426.

https://doi.org/10.1093/humupd/dmv016.

Ombelet W., Cooke I., Dyer S., Serour G. and Devroey P. 2008 Infertility and the Provision of Infertility Medical Services in Developing Countries. Hum. Reprod. Update. 14(6): 605–621. https://doi.org/10.1093/humupd/dmn042.

Katsarou A., Gudbjörnsdottir S., Rawshani A., DabeleaD., Bonifacio E., Anderson BJ., Jacobsen LM., Schatz DA. andLernmark K. 2017 Type 1 diabetes mellitus. Nat. Rev. Disease Prim. 3(1). https://doi.org/10.1038/nrdp.2017.16.

Olokoba AB., Obateru OA. and Olokoba LB. 2012 Type 2 diabetes mellitus: a review of current trends. Oman med. J. 27(4): 269–273. https://doi.org/10.5001/omj.2012.68.

Murea M., Ma L. and Freedman BI. 2012 Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. The Rev. Diabet. Stud. 9(1):6–22. https://doi.org/10.1900/rds.2012.9.6.

Ismail L., Materwala H. and Al Kaabi J. 2021 Association of risk factors with type 2 diabetes: A systematic review. Computation. Struc. Biotechnol. J. 19: 1759–1785. https://doi.org/10.1016/j.csbj.2021.03.003.

Saha A., Samadder A. and Nandi S. 2022 Stem Cell therapy in combination with naturopathy: Current progressive management of diabetes and associated complications. Curr. Top. Med. Chem. 23: 1–41.

https://doi.org/http://dx.doi.org/10.2174/1568026623666221201150933.

Daneman D. 2006 Type 1 Diabetes. The Lancet. 367 (9513): 847–858. https://doi.org/10.1016/S0140-6736(06)68341-4.

Viollet B., Guigas B., Garcia NS., Leclerc J., Foretz M. and Andreelli F. 2012 Cellular and Molecular Mechanisms of Metformin: An Overview. Clinic. Sci. 122 (6): 253–270. https://doi.org/10.1042/CS20110386.

Proks P., Reimann F., Green N., Gribble F. and Ashcroft, F. 2002 Sulfonylurea Stimulation of Insulin Secretion. Diabetes. 51 (suppl_3): S368–S376. https://doi.org/10.2337/diabetes.51.2007.S368.

Hurren KM. and Dunham MW. 2021 Are Thiazolidinediones a Preferred Drug Treatment for Type 2 Diabetes? Expert Opin. Pharmacoth. 22 (2): 131–133.

https://doi.org/10.1080/14656566.2020.1853100.

Saha A., Samadder A. and Nandi S. 2022 Stem Cell therapy in combination with naturopathy: Current progressive management of diabetes and associated complications. Curr. Top. Medicin. Chem. 23: 1–41.

https://doi.org/http://dx.doi.org/10.2174/1568026623666221201150933.

Bansal AK., Bilaspuri GS. 2011 Impacts of Oxidative

Stress and Antioxidants on Semen Functions. Veterin. Med. Internat. 2011, 1–7. Curr. Top. Medicin. Chem. 686137, 2011: 1-7. doi:10.4061/2011/686137.

Ahmad G., Sharma R., Roychoudhary S., Esteves S. and Agarwal A. 2016 Efficacy of Ascorbic Acid in Alleviating Oxidative Stress Using In-Vitro Human Sperm Model. Fertil. Steril. 106 (3): e289.

https://doi.org/10.1016/j.fertnstert.2016.07.1109.

Wong WY., Thomas CMG., Merkus JMWM., Zielhuis GA. and Steegers-Theunissen RPM. 2000 Male Factor Subfertility: Possible Causes and the Impact of Nutritional Factors. Fertil. Steril. 73 (3): 435–442.

https://doi.org/10.1016/S0015-0282(99)00551-8.

Downloads

Published

2022-12-31

How to Cite

Moitra, S. (2022). Perilous influence of diabetes mellitus on fertility: possible and progressive future approaches and treatments to cure. International Journal of Advanced Research Trends in Science, 1(1), 41–44. https://doi.org/10.70035/ijarts.2022.1141-44

Issue

Section

Original Research Article